I teach or have previously taught the courses listed below in Bioengineering, Biology/Biotechnology, and Chemistry. I also work with students on research projects and independent studies.BEN 480 Bioengineering Semester Internship
B.S.E. with Honors and Distinction, Biomedical Engineering - University of Iowa College of Engineering
Honors Thesis: The role of the cytoskeleton in protein trafficking by the Golgi apparatus
Ph.D., Biological Chemistry - University of Texas-Southwestern Medical Center
Dissertation: Rab5 activating proteins and their regulation of endocytosis and cell signaling
Post-doctoral Certificate in Research - University of Texas-Southwestern Medical Center
Focus: Continuing Education in Teaching, Research Methods, Ethics
- National Science Foundation Pre-doctoral Fellowship (2001) “ Regulation of intra-organelle trafficking of the SCAP-SREBP complex ($124,000)
- Ruth L. Kirschstein National Research Service Award “ National Institutes of Health (2007)“ Identification of signal-induced splicing regulators ($101,000)
- North Park University Individual Development Program Grant (2009)“ Molecular characterization of Borrelia burgdorferi, the causative agent of Lyme disease ($2,500), with Dr. Matthew Schau
- Tri Beta Research Award (2009)“ Molecular characterization of Borrelia burgdorferi from the Chicagoland Area ($1,200), with Dr. Matthew Schau and students
- Tri Beta Research Award (2010)“Surveillance for the prevalence of Anaplasma phagocytophilum in the Chicagoland area ($1,160), with Dr. Matthew Schau and students
- American Society for Microbiology Student Travel Grant Award (2012) “ OspC genotyping of Borrelia burgdorferi reveals significant heterogeneity in Chicagoland area ($500), with Dr. Matthew Schau and research assistant Tyler Nelson
- LI-COR Biosciences Science Undergraduate Research Grant (2013)“ For purchase of Odyssey Fc Imaging System ($18,400)
- BioLogos Evolution and Christian Faith Grant (2013) “ Moving pastors toward scientific literacy ($204,100), with Dr. Craig Story
- Massachusetts Life Science Center Capital Grant (2014) “ Equipment and facility upgrades for the Life Sciences Consortium of the North Shore ($5,000,000), with Dr. Gene Wong and other members of the Steering Committee
My research interests are diverse and have included: 1) characterization of the Alsin, a protein mutated in several juvenile neurodegenerative disorders; 2) identification of tick-borne infectious agents in urban and rural environments in collaboration with Greg Keller at Gordon College and Jeff Nelson, Drew Rholl, and Matt Schau at North Park University; 3) alternative splicing of pre-mRNA upon T cell activation. He has received funding from the NSF, NIH, and small private organizations. I was also awarded a grant from Biologos with Craig Story at Gordon College to explore the relationship of science and religion. I love working with students on research projects!
- Ahluwalia, J.P., Topp, J.D., Weirather, K., Zimmerman, M., and M. Stamnes (2001). A role for calcium in stabilizing transport vesicle coats. Journal of Biological Chemistry 276: 34148-34155.
- Davies, B.A., Topp, J.D., Sfeir, A.J., Katzmann, D.J., Carney, D.S., Tall, G.G., Friedberg, A.S., Deng, L., Chen, Z., and B.F. Horazdovsky (2003). Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic. Journal of Biological Chemistry 278: 19826-19833.
- Topp, J.D., Gray N.W., Gerard, B., and B.F. Horazdovsky (2004). Alsin is a Rab5 and Rac1 exchange factor. Journal of Biological Chemistry 279: 24612-24623.
- Devon, R.S., Schwab, C., Topp, J.D., Orban, P.C., Yang, Y., Pape, T.D., Helm, J.R., Davidson, T., Rogers, D.A., Gros-Luis, F., Rouleau, G., Horazdovsky, B.F., Leavitt, B.R., and M.R. Hayden (2005). Cross-species characterization of the Als2 gene and analysis of its pattern of expression in development and adulthood. Neurobiology of Disease 18: 243-257. (cover)
- Topp, J.D., Carney, D.S., and B.F. Horazdovsky (2005). Biochemical characterization of Alsin, a Rab5 and Rac1 guanine nucleotide exchange factor. Methods in Enzymology 403: 261-275.
- Ip, J., Tong, A., Pan, Q., Topp, J.D., Blencowe, B.J., and K.W. Lynch (2007). Global analysis of alternative splicing during T cell activation. RNA 13: 563-572.
- Topp, J.D., Jackson, J., Melton, A.A., and K.W. Lynch (2008). A cell-based screen for splicing regulators identifies hnRNPLL as a distinct signal-induced repressor of CD45 variable exon 4. RNA 14: 2038-2049.
- J.D. Topp (2015). Alsin. UCSD Molecule Pages. doi: 10.6072/H0.MP.A004773.01. Published online 20 July 2015.
- A. Martin* and J.D. Topp (2016). Alsin. Encyclopedia of Signaling Molecules, 2nd ed. in press.
- Topp, J.D.#, Chen, G., Severson, S.R., and B.F. Horazdovsky#. Alsin mediates IGF-1 receptor signaling and cell survival. (in revision)
# indicates co-corresponding authors * indicates undergraduate co-author
- J.D. Topp (2008). Review of A Scientific Search for Religious Truth by P. Mundt. Perspectives on Science and Christian Faith 60: 200.
- J.D. Topp (2008). Review of Evolution and Religious Myths: How Scientists Respond by P.F. Lurquin and L. Stone. Perspectives on Science and Christian Faith 60: 202-203.
- J.D. Topp (2012). Review of Life's X Factor: The Missing Link in Materialism's Science of Living Things by N. Broom. Perspectives on Science and Christian Faith 64: 255-256. (invited)
- J.D. Topp (2013). Review of Origins: Christian Perspectives on Creation, Evolution, and Intelligent Design by D.B. Haarsma and L.D. Haarsma. Perspectives on Science and Christian Faith 65: 210-212. (invited)
- J.D. Topp (2013). Review of Science, Creation, and the Bible by R.F. Carlson and T. Longman III. Reports of the National Center for Science Education 33: 10.1-3. (invited)
- J.D. Topp (2010). Review of Galileo Goes to Jail and Other Myths about Science and Religion edited by Ronald L. Numbers. Jesus Creed blog. http://www.patheos.com/blogs/jesuscreed/2010/07/03/saturday-afternoon-book-review-justin-topp/ (published 3 July 2010).
- J.D. Topp (2010). Evangelicalism, adaptation, and the personal. Science & the Sacred Blog, BioLogos Foundation. http://biologos.org/blogs/guest/evangelicalism-and-adaptation/ (published 13 July 2010).
- J.D. Topp (2010). Review of Evolving in Monkey Town by Rachel Held Evans. Jesus Creed blog. http://www.beliefnet.com/columnists/jesuscreed/2010/08/evolving-in-monkey-town-justin.html (published 10 August 2010).
- J.D. Topp (2011). With respect to nature.Covenant Companion Feb 2011: 22-25. (invited)
- J.D. Topp (2014). Lakatos and the creation-evolution œdiscussion. Two-part series, Science & the Sacred Blog, BioLogos Foundation. http://biologos.org/blogs/archive/lakatos-and-the-creation-evolution-discussion-part-2 (published 24 and 25 February 2014).
- J.D. Topp (2015). Creation and evolution œresearch programs (and why it™s so hard to change perspectives). Science & the Sacred Blog, BioLogos Foundation. http://biologos.org/blogs/archive/creation-and-evolution-research-programs-and-why-its-so-hard-to-change-perspectives (published 29 July 2015).
- J.D. Topp (2016). Essential Kenosis as a Model for Science and Religion Integration. Essay on Thomas™s Oord™s book The Uncontrolling Love of God: An Open and Relational Account of Providence on the For the Love of Wisdom and the Wisdom of Love blog. (published 22 September 2016)
I also maintain a personal blog on the constructive interface of science and religion called a biologist™s view of science and religion (www.scienceandtheology.wordpress.com) that has amassed nearly 80,000 hits.
- Stamnes, M.A., Vadakkan, C., Navarette-Alonso, A., Topp, J., and R. Fucini (1999). ARF regulation of Golgi-bound cytoskeletal proteins. 39th American Society for Cell Biology Annual Meeting.
- Ahluwalia, J.P., Topp, J.D., Weirather, K., Zimmerman, M., and M. Stamnes (2000). A role for calcium in stabilizing the coat on Golgi-derived transport vesicles. 40th American Society for Cell Biology Annual Meeting.
- Ahluwalia, J.P., Chen, J.L., Topp, J.D., Weirather, K., and M. Stamnes (2001). The effect of calcium modulation on the integrity of transport vesicle coat and on Golgi trafficking. 52nd American Association for the Study of Liver Diseases Meeting.
- Davies, B.A., Topp, J.D., Sfeir, A., Carney, D.S., Tall, G.G., Friedberg, A.S., and B.F. Horazdovsky (2002). The Rab guanine nucleotide exchange factor Vps9p is monubiquitinated and is required for the efficient trafficking of proteins through the endocytic pathway. 42nd American Society for Cell Biology Annual Meeting.
- J.D. Topp and B.F. Horazdovsky (2002). Alsin is a Rab5 guanine nucleotide exchange factor. 42nd American Society for Cell Biology Annual Meeting.
- Topp, J.D., Severson, S.R., Devon, R.S., Orban, P.C., Hayden, M.R., and B.F. Horazdovsky (2005). Alsin mediates IGF-1 receptor signaling and cell survival. 45th American Society for Cell Biology Annual Meeting.
- J.D. Topp and K.W. Lynch (2006). A genetic screening method to identify regulators of signal-induced Splicing. 4th Annual Postdoctoral Symposium and Poster Session (University of Texas-Southwestern Medical Center).
- J.D. Topp and K.W. Lynch (2006). A genetic screening method to identify regulators of signal-induced splicing that incorporates transcriptional synergy to amplify changes in splicing. RNA Society Annual Meeting.
- Horazdovsky, B.F., Topp, J.D., Chen, G., and S.R. Severson (2009). Rab5 guanine nucleotide exchange factors: regulators of receptor trafficking from yeast to neurons. American Society for Neurochemistry 40th Annual Meeting.
- J.D. Topp (2009) Enhancing critical thinking skills in an upper-level biology course. Associated Colleges of the Chicago Area 5th Annual Scholarship of Pedagogy Symposium.
- J.D. Topp and M.D. Schau (2010). Reflections on a year co-mentoring a research lab. Associated Colleges of the Chicago Area 6th Annual Scholarship of Pedagogy Symposium.
- Cholewinski, M.*, Ondrey, J.*, Meyers, M.*, Morrison, R.*, Schau, M.D., and J.D. Topp (2010). Genotyping and molecular fingerprinting analysis reveals the prevalence of Borrelia burgdorferi sensu stricto in the Chicagoland area. 70th Annual Meeting of the North Central Branch of the American Society for Microbiology. Awarded 2nd Place Poster, Undergraduate Division.
- Nelson, T.*, Koubsky, E.*, Nelson, J.A., Topp, J.D., and M.D. Schau (2012). OspC genotyping of Borrelia burgdorferi reveals significant heterogeneity in Chicagoland area. 112th General Meeting of the American Society for Microbiology.
- Carlson, T.*, Nam, H.*, Versland, L.*, Rholl, D.*, Nelson, J.A., Schau, M.D., and J.D. Topp (2012). MLST analysis of Borrelia isolates from the Chicago Area. 112th General Meeting of the American Society for Microbiology.
- Topp, J.D., Nold, M., Abrams, E.S., Farnsworth, C.L., Geromanos, S., Askenazi, M., and J.C. Silva (2013). Using orthogonal techniques for protein-peptide separation to generate comprehensive HDMSe mass spectral libraries from an E. coli model system. 61st American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics.
- C.M. Story and J.D. Topp (2013). Promoting scientific literacy in pastors. American Scientific Affiliation Annual Meeting.
- Mason, S.D.*, Sherratt, S.C.R.*, Kruguer, S.M.*, Muthersbaugh, M.*, Topp, J.D., and G.S. Keller (2014). Shifts in small-mammal abundance and Lyme disease infection rate at varying scales among four different New England habitat types. 2014 Northeast Natural History Conference.
- Kruguer, S.M.*, Mason, S.D.*, Keller, G.S., and J.D. Topp (2014). Effects of habitat and vegetation on abundance of black-legged ticks (Ixodes scapularis) as Lyme Disease carriers in Essex County, Massachusetts. 2014 Northeast Natural History Conference.
- Sherratt, S.C.R.*, Mason, S.D.*, Kruguer, S.M.*, Muthersbaugh, M.*, Vierra, E.*, Keller, G.S., and J.D. Topp (2014). Effects of forest fragmentation on reservoir abundance and the prevalence of Lyme disease-causing Borrelia burgdorferi sensu stricto in Essex County, Massachusetts. 114th General Meeting of the American Society for Microbiology.
- C.M. Story and J.D. Topp (2014). Creating a course for pastors on science and faith. 2014 BioLogos Evolution and Christian Faith Workshop.
- Kruguer, S.*, Keller, G.S., and J.D. Topp (2015). Effects of landscape fragmentation, habitat, and vegetation on abundance of Ixodes scapularis as a Lyme disease carrier in Essex County, Massachusetts. 2015 Experimental Biology Annual Conference.
- J.D. Topp (2015). Creating a course for pastors on science and faith. Evolution and Christian Faith: A BioLogos Conference.
* indicates undergraduate co-author
I joined Endicott in the summer of 2014 as Assistant Dean of Science, Technology, and Mathematics and Associate Professor of Biology and Bioengineering. I oversee Endicott's programs in Applied Mathematics, Bioengineering, Biology and Biotechnology, Computer Science, Environmental Science, and Mathematics. This involves working with faculty to refine and assess existing curricula, to develop new programs in related areas, and to pursue grants that support programs and undergraduate research. I also teach, perform research with undergraduates, and serve or chair a number of committees including Assessment, Institutional Review Board, Professional Development, Thesis Day, and faculty or dean search committees.
With Gene Wong, Dean of Arts and Sciences at Endicott, I am an active participant in the recently formed Life Sciences Consortium of the North Shore. This consortium, a partnership between Endicott and other neighboring institutions, was recently awarded a $5mil grant from the Massachusetts Life Science Center to promote the biotechnology industry in the North Shore area. I am very excited to partner with local companies to better integrate Endicott undergraduate programs with industry needs and provide our students the best internship sites (and ensure that our students are well prepared for them!). To this end I also serve on the North Shore Technology Council Operations Board.
Prior to Endicott, I taught in the Departments of Biology at North Park University (2008-2011) and Gordon College (2011-2014) as Assistant Professor and Associate Professor, respectively. I earned a B.S.E. in Biomedical Engineering with Honors and Distinction from the University of Iowa before pursuing a Ph.D. and Post-doctoral fellowship in Biological Chemistry from the University of Texas-Southwestern Medical Center.